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Anafranil (Clomipramine)

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What is Anafranil (clomipramine) prescribed for?

Anafranil is a prescription tricyclic antidepressant used for the symptoms of obsessive-compulsive disorder that may prevent the patient from enjoying the normal flow of life. Such symptoms as repetitive actions (doing something over and over again) and recurrent thoughts/feelings may be treated with the help of clomipramine. Anafranil works for the patient by affecting chemicals in the brain that can get imbalanced due to reasons that are still unknown to scientists.

Contraindications for using Anafranil

You need to know that Anafranil is not supposed to be taken by those with a recent history of a heart attack, as well as patients who used any MAO inhibitors (like isocarboxazid, phenelzine, tranylcypromine, rasagiline and selegiline) in the last 14 days. Patients allergic to doxepin, protriptyline, amitriptyline, nortriptyline, desipramine, trimipramine, imipramine or amoxapine are also not supposed to start clomipramine treatment, because they are likely to develop the same effects all over again. In that case, it's best to look for a safer alternative.

Before Anafranil (clomipramine) treatment can be started

Tell your doctor if you have a history of heart attack or stroke, schizophrenia, liver disease, a history of seizures, trouble urinating, overactive thyroid, glaucoma, kidney disease, bipolar disorder, adrenal gland tumor or heart disease, or any other medical conditions likely to affect your treatment and the dose of Anafranil you need.

How is Anafranil (clomipramine) taken?

Make sure you always take clomipramine exactly as prescribed by your health care provider without exceeding the dose or taking less than you are supposed to. Your dose of Anafranil may need to be changed occasionally for you to get the most out of your treatment. You may need to be taking Anafranil with some food to avoid or reduce stomach upset possible otherwise. You may need to stop Anafranil treatment if you need a surgery. Tell your surgeon about taking clomipramine in advance. Some 4 weeks may be required for the patient to notice the effects of Anafranil, and you need to keep taking this drug all the time. When you need to stop the treatment, talk to your health care provider before you do so, as stopping your Anafranil treatment suddenly can cause withdrawal symptoms. Talk to your health care provider if your symptoms do not get better after 4 weeks of regular clomipramine treatment.

Can Anafranil (clomipramine) interact with other medications I am using?

You may be able to take Anafranil with some other medications, but keep in mind that some of them can worsen your side effects or reduce the efficiency of clomipramine treatment, especially warfarin, blood pressure medications, muscle relaxers, heart medicine, medicine for seizures, pain medication, heart rhythm drugs, anti-psychotic medications, cimetidine, guanethidine, phenytoin, other antidepressants or methylphenidate.

Anafranil (clomipramine) and pregnancy

There is a chance Anafranil may harm your child if you take it when pregnant. Make sure you avoid Anafranil treatment if you are expecting a child or are currently planning a pregnancy, as you may not be able to start your treatment and carry on with it safely. Also, tell your doctor if you are breastfeeding, as clomipramine can pass in your breast milk, and there is a chance it will affect your child.

Is Anafranil (clomipramine) overdose dangerous?

An overdose of Anafranil can be fatal unless you seek emergency medical help. The following symptoms indicate clomipramine overdose: extreme drowsiness, light-headedness, seizure, uneven heart rate, fainting, agitation, sweating, muscle stiffness, confusion, shortness of breath, increased or decreased urination, vomiting, swelling, blue lips or fingernails and blurred vision.

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